Combinations of artemisinin and quinine for uncomplicated falciparum malaria: efficacy and pharmacodynamics.

@article{Vries2000CombinationsOA,
  title={Combinations of artemisinin and quinine for uncomplicated falciparum malaria: efficacy and pharmacodynamics.},
  author={Peter M. J. M. De Vries and Nguyen Ho Ngoc Bich and Huynh van Thien and Le Ngoc Hung and T K Anh and Piet A. Kager and S H Heisterkamp},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 5},
  pages={1302-8}
}
Combinations of artemisinin and quinine for uncomplicated falciparum malaria were studied. A total of 268 patients were randomized to 7 days of quinine at 10 mg/kg of body weight three times a day (Q) or to artemisinin at 20 mg/kg of body weight followed by 3 (AQ3) or 5 (AQ5) days of quinine. Recrudescence rates were 16, 38, and 15% for the Q, AQ3, and AQ5 groups, respectively (P < 0.001). Recrudescence was associated with shorter parasite clearance time (PCT) and longer treatment after the… CONTINUE READING

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