Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma

@inproceedings{Gill2015CombinationsOP,
  title={Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma},
  author={Sonja J. Gill and Jon Travers and Irina Pshenichnaya and Fiona A. Kogera and Syd Barthorpe and Tatiana Mironenko and Laura B Richardson and Cyril H Benes and Michael R. Stratton and Ultan McDermott and Stephen P. Jackson and Mathew J. Garnett and Robert William Sobol},
  booktitle={PloS one},
  year={2015}
}
Ewing's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease. Ewing's sarcoma cells are acutely hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibition and this is being evaluated in clinical trials, although the mechanism of hypersensitivity has not been directly addressed. PARP inhibitors have efficacy in tumors with BRCA1/2 mutations, which confer deficiency in DNA double-strand break (DSB) repair by homologous… CONTINUE READING

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Ewing 's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease .
Ewing 's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease .
Ewing 's sarcoma cells are acutely hypersensitive to poly ( ADP - ribose ) polymerase ( PARP ) inhibition and this is being evaluated in clinical trials , although the mechanism of hypersensitivity has not been directly addressed .
Ewing 's sarcoma cells are acutely hypersensitive to poly ( ADP - ribose ) polymerase ( PARP ) inhibition and this is being evaluated in clinical trials , although the mechanism of hypersensitivity has not been directly addressed .
Ewing 's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease .
Ewing 's sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease .
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