Combinational application of surface plasmon resonance spectroscopy and quartz crystal microbalance for studying nuclear hormone receptor-response element interactions.

@article{Su2006CombinationalAO,
  title={Combinational application of surface plasmon resonance spectroscopy and quartz crystal microbalance for studying nuclear hormone receptor-response element interactions.},
  author={X. Su and C. Lin and S. O'Shea and Huey Fang Teh and Wendy Y X Peh and J. Thomsen},
  journal={Analytical chemistry},
  year={2006},
  volume={78 15},
  pages={
          5552-8
        }
}
  • X. Su, C. Lin, +3 authors J. Thomsen
  • Published 2006
  • Chemistry, Medicine
  • Analytical chemistry
  • Conventional methodologies for studying protein-DNA complexes, such as electrophoretic mobility shift assays (EMSAs), lack the real-time sensitivity and precision to accurately characterize the complex dynamics of interactions between transcription factors and their binding sites. To better understand the interactions between estrogen receptor (ER) subtypes and the estrogen response elements (EREs), we employed surface plasmon resonance (SPR) spectroscopy and quartz crystal microbalance with… CONTINUE READING
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