Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis

@article{Lee2009CombinationTW,
  title={Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis},
  author={S.-S. Lee and Y.-W. Park and J-J Park and Ym Kang and Ej Nam and Sik Kim Kwang Sik Kim and Jh Lee and Wan-Hee Yoo and S.I.L. Lee},
  journal={Scandinavian Journal of Rheumatology},
  year={2009},
  volume={38},
  pages={11 - 14}
}
Objective: To determine the efficacy and safety of the combination of leflunomide and methotrexate for the treatment of patients with active rheumatoid arthritis (RA) in an open, non‐comparative, multicentre trial. Methods: Seventy‐four patients with active RA were enrolled to receive concomitantly leflunomide (no loading dose, 10 mg/day) and methotrexate (starting at 7.5 mg/week and titrating up to 15 mg/week) for 20 weeks. The primary end‐point was a 20% improvement in the American College of… 

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The ETN+MTx combination therapy was effective and safe, whereas the LEF+MTX combination therapy resulted in moderate efficacy in only half of the cases, and was accompanied by a high rate of adverse events.

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