Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.

@article{Gottwein2013CombinationTW,
  title={Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.},
  author={Judith M. Gottwein and Sanne B Jensen and Yi-Ping Li and Lubna Ghanem and Troels K H Scheel and St{\'e}phanie B N Serre and Lotte S. Mikkelsen and Jens Bukh},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 3},
  pages={1291-303}
}
With the development of directly acting antivirals, hepatitis C virus (HCV) therapy entered a new era. However, rapid selection of resistance mutations necessitates combination therapy. To study combination therapy in infectious culture systems, we aimed at developing HCV semi-full-length (semi-FL) recombinants relying only on the JFH1 NS3 helicase, NS5B, and the 3' untranslated region. With identified adaptive mutations, semi-FL recombinants of genotypes(isolates) 1a(TN) and 3a(S52) produced… CONTINUE READING
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