Combination treatment of vitamin C and desferrioxamine suppresses glomerular superoxide and prostaglandin E production in diabetic rats.

@article{Iino2005CombinationTO,
  title={Combination treatment of vitamin C and desferrioxamine suppresses glomerular superoxide and prostaglandin E production in diabetic rats.},
  author={Kenzo Iino and Masanori Iwase and Kazuo Sonoki and Mototaka Yoshinari and Mitsuo Iida},
  journal={Diabetes, obesity & metabolism},
  year={2005},
  volume={7 1},
  pages={106-9}
}
AIMS Increased oxidative stress may contribute to the development of diabetic nephropathy. Conversely, it has been proposed that enhanced glomerular production of prostaglandin E(2) (PGE(2)) may be the cause of glomerular hyperfiltration in streptozotocin (STZ)-induced diabetic rats. As the role of superoxide anion (O(2-)) production in early diabetic nephropathy is not fully understood, we investigated the effect of vitamin C and desferrioxamine treatment on glomerular O(2-) and PGE(2… CONTINUE READING