Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy.

@article{Lohr2000CombinationTO,
  title={Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy.},
  author={Frank Lohr and Kang Quan Hu and Zishan A. Haroon and Thaddeus V. Samulski and Qian Huang and Jennifer Beaty and Mark W. Dewhirst and Canhui Li},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2000},
  volume={2 3},
  pages={195-203}
}
Failure of local tumor control still poses a problem for radiotherapy and translates into reduced survival. Combining radiation with chemotherapy or other newer modalities has shown promising results. Immunological approaches to tumor therapy have found renewed interest due to improved insight into mechanisms involved in the immune response to tumors. In this paper, we studied tumor growth delay after various combination regimens of locally injected adenovirus constitutively expressing IL12 and… CONTINUE READING