Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.

@article{Belinsky2011CombinationTW,
  title={Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.},
  author={Steven Alan Belinsky and Marcie J. Grimes and Maria A. Picchi and Hugh D. Mitchell and Chris A Stidley and Yohannes Tesfaigzi and Meghan M. Channell and Yanbin Liu and Robert Anthony Casero and Stephen B. Baylin and Mathew D Reed and Carmen Tellez and Thomas H. March},
  journal={Cancer research},
  year={2011},
  volume={71 2},
  pages={454-62}
}
Epigenetic therapy for solid tumors could benefit from an in vivo model that defines tumor characteristics of responsiveness and resistance to facilitate patient selection. Here we report that combining the histone deacetylase inhibitor entinostat with the demethylating agent vidaza profoundly affected growth of K-ras/p53 mutant lung adenocarcinomas engrafted orthotopically in immunocompromised nude rats by targeting and ablating pleomorphic cells that occupied up to 75% of the tumor masses. A… CONTINUE READING

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