Combination therapy with thymosin alpha 1 potentiates the anti-tumor activity of interleukin-2 with cyclophosphamide in the treatment of the Lewis lung carcinoma in mice.

@article{Mastino1992CombinationTW,
  title={Combination therapy with thymosin alpha 1 potentiates the anti-tumor activity of interleukin-2 with cyclophosphamide in the treatment of the Lewis lung carcinoma in mice.},
  author={Antonio Mastino and Cartesio Favalli and Sandro Grelli and Guido Rasi and Francesca Pica and Allan L. Goldstein and Enrico Garaci},
  journal={International journal of cancer},
  year={1992},
  volume={50 3},
  pages={493-9}
}
In this study we have investigated the effects of thymosin alpha 1 (T alpha 1) and interleukin-2 (IL-2), singly or in combination with cyclophosphamide (CY), on tumor growth, survival and cytotoxicity in C57Bl/6NCrlBR mice with Lewis lung carcinoma (3LL). Combined administration of T alpha 1 plus IL-2, after CY treatment, was much more effective than use of each biological response modifier (BRM) alone, and induced complete tumor regression in all of the mice studied. Combination immunotherapy… CONTINUE READING
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