Combination therapy with polymyxin B for the treatment of multidrug-resistant Gram-negative respiratory tract infections.

@article{Sobieszczyk2004CombinationTW,
  title={Combination therapy with polymyxin B for the treatment of multidrug-resistant Gram-negative respiratory tract infections.},
  author={Magdalena E. Sobieszczyk and E. Yoko Furuya and Christine Mhorag Hay and Preeti Pancholi and Phyllis A. Della-Latta and Scott M. Hammer and Christine J. Kubin},
  journal={The Journal of antimicrobial chemotherapy},
  year={2004},
  volume={54 2},
  pages={566-9}
}
BACKGROUND The treatment of infections caused by multidrug-resistant (MDR) Gram-negative organisms poses a therapeutic challenge. The use of polymyxin B has been resurrected specifically for this purpose. PATIENTS AND METHODS We retrospectively reviewed the clinical and microbiological efficacy, and safety profile of polymyxin B in the treatment of MDR Gram-negative bacterial infections of the respiratory tract. Twenty-five critically ill patients received a total of 29 courses of polymyxin B… CONTINUE READING