Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate.

@article{Carmichael2002CombinationTW,
  title={Combination therapy with methotrexate and hydroxychloroquine for rheumatoid arthritis increases exposure to methotrexate.},
  author={Samantha J Carmichael and Joanne Beal and Richard O. Day and Susan E. Tett},
  journal={The Journal of rheumatology},
  year={2002},
  volume={29 10},
  pages={2077-83}
}
OBJECTIVE To examine the bioavailability of methotrexate (MTX) in the presence of hydroxychloroquine (HCQ), and vice versa, to determine a possible pharmacokinetic explanation for the observation that combination treatment of rheumatoid arthritis with MTX and HCQ has been shown, clinically, to be more potent than MTX used alone. METHODS In a randomized crossover study, 10 healthy subjects received, on each of 5 dosing occasions, MTX alone as tablets or intravenous solution, HCQ alone as a… CONTINUE READING

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