Combination therapy with lamivudine and adenovirus causes transient suppression of chronic woodchuck hepatitis virus infections.

@article{Zhou2000CombinationTW,
  title={Combination therapy with lamivudine and adenovirus causes transient suppression of chronic woodchuck hepatitis virus infections.},
  author={Tianlun Zhou and Ju-Tao Guo and Frederick A. Nunes and Katherine L. Molnar-Kimber and Joelle M Wilson and Carol E Aldrich and Jeffry R Saputelli and Sam Litwin and Lynn D. Condreay and Christoph Seeger and William S. Mason},
  journal={Journal of virology},
  year={2000},
  volume={74 24},
  pages={11754-63}
}
Treatment of hepatitis B virus carriers with the nucleoside analog lamivudine suppresses virus replication. However, rather than completely eliminating the virus, long-term treatment often ends in the outgrowth of drug-resistant variants. Using woodchucks chronically infected with woodchuck hepatitis virus (WHV), we investigated the consequences of combining lamivudine treatment with immunotherapy mediated by an adenovirus superinfection. Eight infected woodchucks were treated with lamivudine… CONTINUE READING