Combination therapy with fluconazole and flucytosine for pulmonary cryptococcosis.

  title={Combination therapy with fluconazole and flucytosine for pulmonary cryptococcosis.},
  author={Yasuhisa Yamamoto and Shigefumi Maesaki and Hiroshi Kakeya and Katsunori Yanagihara and Hideaki Ohno and Kenji Ogawa and Yoichi Hirakata and Kazunori Tomono and Takayoshi Tashiro and Shigeru Kohno},
  volume={43 6},
We investigated, in vitro, the combined effects of fluconazole (FLCZ) and flucytosine (5-FC) against different strains of Cryptococcus neoformans, and retrospectively analyzed the clinical efficacy of combination therapy of FLCZ and 5-FC in patients with pulmonary cryptococcosis. The minimum inhibitory concentrations (MICs) of antifungal agents and drug interaction were determined by the broth microdilution method and checkerboard titration. FLCZ and 5-FC showed synergistic activity against 8… CONTINUE READING