Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice.

@article{Spellberg2005CombinationTW,
  title={Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice.},
  author={Brad J. Spellberg and Yue Fu and John E. Edwards and Ashraf S Ibrahim},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 2},
  pages={830-2}
}
We studied the combination of amphotericin B lipid complex (ABLC) and caspofungin in mice with disseminated Rhizopus oryzae. Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls (P < 0.05) but did not improve organ clearance. In addition, prophylactic combination therapy was not more effective than prophylactic ABLC alone.