Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma.

  title={Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma.},
  author={Aaron Deykin and Michael E. Wechsler and Homer A. Boushey and Vernon M. Chinchilli and Susan J Kunselman and Timothy John Craig and Emily A. Dimango and John V Fahy and Monica Kraft and Frank T. Leone and Stephen C. Lazarus and Robert F. Lemanske and Richard J. Martin and Gene Raymond Pesola and Stephen P. Peters and Christine A. Sorkness and Stanley J Szefler},
  journal={American journal of respiratory and critical care medicine},
  volume={175 3},
RATIONALE Long-acting beta-agonists (LABAs) and inhaled corticosteroids administered together appear to be complementary in terms of effects on asthma control. The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well. OBJECTIVE We sought to determine whether the combination of the LTRA montelukast and the LABA salmeterol could provide an effective therapeutic strategy… CONTINUE READING
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