Combination therapy using fexofenadine, disodium cromoglycate, and a hypoallergenic amino acid-based formula induced remission in a patient with steroid-dependent, chronically active ulcerative colitis

@article{Raithel2006CombinationTU,
  title={Combination therapy using fexofenadine, disodium cromoglycate, and a hypoallergenic amino acid-based formula induced remission in a patient with steroid-dependent, chronically active ulcerative colitis},
  author={Martin Raithel and Sandra Winterkamp and Michael Weidenhiller and S M{\"u}ller and Eckhart G. Hahn},
  journal={International Journal of Colorectal Disease},
  year={2006},
  volume={22},
  pages={833-839}
}
Corticosteroids and 5-aminosalicylic acid are the primary standard therapy for inflammatory bowel disease. Recent immunologic data implicate an involvement of mast cell activation followed by increased histamine secretion and elevated tissue concentrations of histamine in the pathogenesis of ulcerative colitis. In the present case, the clinical course of a 35-year-old man with steroid-dependent chronic active ulcerative colitis, who did not respond to high-dose steroids, antibiotics, or… 
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References

SHOWING 1-10 OF 52 REFERENCES
Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506)
TLDR
Tacrolimus induced rapid remission in steroid resistant inflammatory bowel disease in the majority of cases and appears to be an effective treatment modality that may be superior to cyclosporine with respect to maintenance of remission.
Ketotifen Therapy for Acute Ulcerative Colitis in Children (A Pilot Study)
TLDR
Low-doseketotifen offers a limited therapeutic advantage in active ulcerative colitis that may beenhanced in the subgroup of patients with a higheosinophil count in the colonic mucosa that may be guided by the mast cell stabilizer.
Immunosuppressive drugs in inflammatory bowel disease. A review of their mechanisms of efficacy and place in therapy.
TLDR
Sulphasalazine and 5-aminosalicylic acid are effective in maintenance therapy, but do not act primarily by immunosuppressive mechanisms, and further research into the mechanism of action on the immune response may shed light on the pathogenesis of inflammatory bowel disease.
Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease.
TLDR
A pilot study to determine whether methotrexate has anti-inflammatory activity in refractory inflammatory bowel disease found that 16 of twenty-one patients had an objective response as measured by disease activity indices, and further work is needed before the drug can be recommended forinflammatory bowel disease.
Disodium cromoglycate in the treatment of chronic proctitis.
TLDR
Patients who responded to DSCG had significantly more eosinophils in their rectal biopsies than those who failed to respond and in some instances the counts were very high.
Allergic proctitis, a clinical and immunopathological entity.
TLDR
It is concluded that, in patients with isolated proctitis with a typical clinical picture consisting of a mild and intermittent course of the disease with the presenting symptom of rectal blood loss, a group can be separated which responds to DSCG, a condition for which the name 'allergicProctitis' is suggested.
Treatment of ulcerative colitis.
TLDR
Advances in the treatment of ulcerative colitis have continued to focus on improved local delivery of existing agents, such as 5-aminosalicylate and corticosteroids, and on novel immunosuppressive agents and the role of antibiotics has continued to present controversy.
...
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