Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model.

@article{McCausland2010CombinationTO,
  title={Combination therapy of vaccinia virus infection with human anti-H3 and anti-B5 monoclonal antibodies in a small animal model.},
  author={Megan M. McCausland and Mohammed Rafii-El-idrissi Benhnia and Lindsay Crickard and James B. Laudenslager and Steven W. Granger and Tomoyuki Tahara and Ralph Teruo Kubo and Lilia K. Koriazova and Shinichiro Kato and Shane Crotty},
  journal={Antiviral therapy},
  year={2010},
  volume={15 4},
  pages={
          661-75
        }
}
BACKGROUND Treatment of rare severe side effects of vaccinia virus (VACV) immunization in humans is currently very challenging. VACV possesses two immunologically distinct virion forms in vivo - intracellular mature virion (MV, IMV) and extracellular virion (EV, EEV). METHODS Antibody-mediated therapeutic efficacy was determined against VACV infection in a small animal model of progressive vaccinia. The model consisted of severe combined immunodeficiency mice infected with VACV New York City… CONTINUE READING

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