Combination therapy of prednisolone and mizoribine improves cryoglobulinemic vasculitis with purpura and skin ulcers

@article{Hamaguchi2006CombinationTO,
  title={Combination therapy of prednisolone and mizoribine improves cryoglobulinemic vasculitis with purpura and skin ulcers},
  author={Masahide Hamaguchi and Yutaka Kawahito and Yasunori Tsubouchi and Masataka Kohno and Aihiro Yamamoto and Hidetaka Ishino and Makoto Wada and Toshikazu Yoshikawa},
  journal={Clinical Rheumatology},
  year={2006},
  volume={26},
  pages={1170-1172}
}
Conventional treatment is not standardized for hepatitis C virus-negative cryoglobulinemia, but corticosteroids, immunosuppressive agents, and plasma exchange typically improved the symptoms. Mizoribine is an immunosuppressive agent that was developed in Japan and has been found to inhibit the proliferation of lymphocytes, especially B cells. We have encountered an elder patient who had hepatitis C virus-negative, type II cryoglobulinemic vasculitis with leg purpura and skin ulcers. Her… CONTINUE READING