Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins.

@article{Wada2007CombinationTO,
  title={Combination therapy of interferon-alpha and 5-fluorouracil inhibits tumor angiogenesis in human hepatocellular carcinoma cells by regulating vascular endothelial growth factor and angiopoietins.},
  author={Hiroshi Wada and Hiroaki Nagano and Hirofumi Yamamoto and Isao Arai and Hideo Ota and Masato Nakamura and Bazarragchaa Damdinsuren and Takehiro Noda and Shigeru Marubashi and Atsushi Miyamoto and Yutaka Takeda and Koji Umeshita and Yuichiro Doki and Keizo Dono and Shoji Nakamori and Masato Sakon and Morito Monden},
  journal={Oncology reports},
  year={2007},
  volume={18 4},
  pages={801-9}
}
We recently reported that interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) combination therapy in advanced hepatocellular carcinoma (HCC) achieved excellent clinical results. However, the mechanism underlying this combination therapy remains to be elucidated. In this study, we examined the anti-tumor effects of IFN-alpha and 5-FU combination therapy in vivo and aimed to reveal its anti-angiogenic effects by investigating the expression of vascular endothelial growth factor (VEGF) and… CONTINUE READING
21 Extracted Citations
51 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 21 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 51 references

Similar Papers

Loading similar papers…