Combination therapy of calcium channel blocker and angiotensin II receptor blocker reduces augmentation index in hypertensive patients.

@article{Doi2010CombinationTO,
  title={Combination therapy of calcium channel blocker and angiotensin II receptor blocker reduces augmentation index in hypertensive patients.},
  author={Masayuki Doi and Toru Miyoshi and Satoshi Hirohata and Shigeshi Kamikawa and Shinichi Usui and Youko Kaji and Kosuke Sakane and Hiroko Ogawa and Yoshifumi Ninomiya and Shozo Kusachi},
  journal={The American journal of the medical sciences},
  year={2010},
  volume={339 5},
  pages={433-9}
}
INTRODUCTION The optimal combination treatment for hypertension has not been established. We investigated the effect of a calcium channel blocker or a diuretic added to angiotensin II receptor blockers (ARBs) on the augmentation index (AI), as a marker of arterial stiffness and wave reflection, in hypertensive patients. METHODS Thirty-seven patients treated with ARBs were randomly allocated to either of the 2 groups receiving an ARB plus azelnidipine (AZ group) or trichlormethiazide (TCM… CONTINUE READING

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