Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.

@article{Petraitis2003CombinationTI,
  title={Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.},
  author={Vidmantas Petraitis and Ruta Petraitiene and Alia A Sarafandi and Amy M Kelaher and Caron A. Lyman and Heather E Casler and Tin Aung Sein and Andreas H Groll and John Bach{\'e}r and Nilo A. Avila and Thomas J Walsh},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={187 12},
  pages={1834-43}
}
Invasive pulmonary aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Simultaneous inhibition of fungal cell-wall and cell-membrane biosynthesis may result in synergistic interaction against Aspergillus fumigatus. We studied the antifungal activity of micafungin, a new echinocandin, in combination with ravuconazole, a second-generation triazole, against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits. This combination… CONTINUE READING

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We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
Antifungal AgentsTherapeutic class ofmicafungin
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
An MTT hyphal damage assay demonstrated significant in vitro synergistic interaction between the antifungal triazole and the echinocandin .
Combination therapy in treatment of experimental pulmonary aspergillosis : synergistic interaction between an antifungal triazole and an echinocandin .
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
The combination of an antifungal triazole and echinocandin may represent a new strategy for treatment of invasive pulmonary aspergillosis .
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
ChestIs associated anatomic site ofIdiopathic Pulmonary Fibrosis
Combination therapy also resulted in reduction ( P</=.05 ) of organism - mediated pulmonary injury and of pulmonary infiltrates detected by thoracic computed tomography ( P</=.001 ) .
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
EchinocandinsChemical structure ofmicafungin
We studied the antifungal activity of micafungin , a new echinocandin , in combination with ravuconazole , a second - generation triazole , against experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits .
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