Combination therapy in rheumatoid arthritis: updated systematic review.

@article{Verhoeven1998CombinationTI,
  title={Combination therapy in rheumatoid arthritis: updated systematic review.},
  author={Arco C. Verhoeven and Maarten Boers and Peter Tugwell},
  journal={British journal of rheumatology},
  year={1998},
  volume={37 6},
  pages={
          612-9
        }
}
In a second update of a systematic review, many new developments in the combined drug treatment of rheumatoid arthritis (RA) are highlighted. In early RA patients, step-down bridge therapy that includes corticosteroids leads to much enhanced efficacy at acceptable or low toxicity. The effects on joint damage may be persistent, but the symptomatic effects are probably dependent on continued corticosteroid dosing. In late patients, cyclosporin improves a suboptimal clinical response to… CONTINUE READING

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