Combination therapy for chronic Pseudomonas aeruginosa respiratory infection associated with biofilm formation.

@article{Yanagihara2000CombinationTF,
  title={Combination therapy for chronic Pseudomonas aeruginosa respiratory infection associated with biofilm formation.},
  author={Katsunori Yanagihara and Kazunori Tomono and Toshihiro Sawai and Misuzu Kuroki and Yoshikatsu Kaneko and Hideaki Ohno and Yasuhito Higashiyama and Yoshitsugu Miyazaki and Yoichi Hirakata and Shigefumi Maesaki and Jun-ichi Kadota and Takayoshi Tashiro and Shigeru Kohno},
  journal={The Journal of antimicrobial chemotherapy},
  year={2000},
  volume={46 1},
  pages={69-72}
}
There had been no reports of investigations into biofilms in chronic respiratory infection in vivo. Recently, we established a new murine model of chronic respiratory infection with Pseudomonas aeruginosa. In the present study, we examined the bacteriological effect of combined clarithromycin and levofloxacin against chronic respiratory infection with P… CONTINUE READING