Combination strategy targeting VEGF and HGF/c-met in human renal cell carcinoma models.

Abstract

Alternative pathways to the VEGF, such as hepatocyte growth factor or HGF/c-met, are emerging as key players in tumor angiogenesis and resistance to anti-VEGF therapies. The aim of this study was to assess the effects of a combination strategy targeting the VEGF and c-met pathways in clear cell renal cell carcinoma (ccRCC) models. Male SCID mice (8/group… (More)
DOI: 10.1158/1535-7163.MCT-14-0094

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