Combination particles containing salmeterol xinafoate and fluticasone propionate: Formulation and aerodynamic assessment.

@article{Westmeier2008CombinationPC,
  title={Combination particles containing salmeterol xinafoate and fluticasone propionate: Formulation and aerodynamic assessment.},
  author={Regina Westmeier and Hartwig Steckel},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 6},
  pages={2299-310}
}
A precipitation process is used to produce combined particles consisting of two antiasthmatic drugs: salmeterol xinafoate and fluticasone propionate. To control the crystallisation of these particles, a micromixer is used to mix solvent and antisolvent flow. To produce particles in the respirable range, crystal growth inhibitors are added to the antisolvent flow. The obtained suspension is spray-dried afterwards to get a dry powder which can be further processed into inhalation drug products… CONTINUE READING
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