Combination or single-agent chemotherapy as adjuvant treatment of gastric cancer: A systematic review and meta-analysis of published trials.

@article{Iacovelli2016CombinationOS,
  title={Combination or single-agent chemotherapy as adjuvant treatment of gastric cancer: A systematic review and meta-analysis of published trials.},
  author={Roberto Iacovelli and Filippo Pietrantonio and Claudia Maggi and Filippo Maria De Braud and Maria Di Bartolomeo},
  journal={Critical reviews in oncology/hematology},
  year={2016},
  volume={98},
  pages={24-8}
}
BACKGROUND Chemotherapy is standard care in resected gastric cancer (GC). Despite the evidence that combination chemotherapy (CT) increases overall survival (OS) as compared to single agent therapy in metastatic disease, no study proved this benefit in the adjuvant setting. We performed a systematic review and meta-analysis based on trial data on the role of combination over single agent CT as adjuvant treatment of GC. METHODS MEDLINE/PubMed and Cochrane Library were searched for randomized… CONTINUE READING