Combination of the gamma-glutamyltransferase-to-prealbumin ratio and other indicators may be a novel marker for predicting the prognosis of patients with hepatocellular carcinoma undergoing locoregional ablative therapies

@article{Wang2019CombinationOT,
  title={Combination of the gamma-glutamyltransferase-to-prealbumin ratio and other indicators may be a novel marker for predicting the prognosis of patients with hepatocellular carcinoma undergoing locoregional ablative therapies},
  author={Q. Wang and Peng Zhao and Ning He and J P Sun and K. Li and Chaoran Zang and Y. N. Zhao and Y. N. Zhao and Y. H. Zhang},
  journal={Infectious Agents and Cancer},
  year={2019},
  volume={14}
}
ObjectiveThe aim of this study was to investigate the prognostic significance of the serum γ-glutamyltransferase (γ-GT)-to-prealbumin ratio (GPR) and whether combining this ratio with other parameters can lead to an improved prognostic value for patients with hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE) combined with local ablation therapy.MethodsA total of 235 HCC patients who were treated with combined therapies were retrospectively analyzed. The… 
Exploring the clinical value of preoperative serum gamma-glutamyl transferase levels in the management of patients with hepatocellular carcinoma receiving postoperative adjuvant transarterial chemoembolization
TLDR
It is concluded that patients with more advanced HCC also have more elevated γ-GT, and these patients with elevated ε-GT would be benefited more from PA-TACE after radical resection.
Diagnostic and prognostic value of serum soluble CD163 in cirrhotic patients with hepatitis C virus-related hepatocellular carcinoma before and after locoregional therapy
TLDR
It is concluded that sCD163 has a minor role as a diagnostic marker for HCC, yet it could be used as a good prognostic marker in predicting the tumor response to locoregional therapies.
A scoring model predicting overall survival for hepatocellular carcinoma patients who receive surgery and chemotherapy
TLDR
The constructed scoring model provides reliable and accurate overall survival prediction and a reference for clinicians performing clinical decision-making for hepatocellular carcinoma patients who receive surgery and chemotherapy in the general population.

References

SHOWING 1-10 OF 40 REFERENCES
Prognostic significance of serum gamma-glutamyl transferase in patients with intermediate hepatocellular carcinoma treated with transcatheter arterial chemoembolization
TLDR
GGT level was an important prognostic factor to predict prognosis of patients with intermediate HCC treated with TACE, and the combination of GGT and AFP had a better power to predict the TACE effects.
Predictive value of serum gamma-glutamyltransferase levels in patients with hepatocellular carcinoma.
Here we assessed the predictive value of gamma-glutamyltransferase (γ-GT) for the prognosis of patients with HCC and compared the γ-GT with other prognostic factors. We retrospectively analyzed
Combination of the neutrophil to lymphocyte ratio and the platelet to lymphocyte ratio as a useful predictor for recurrence following radiofrequency ablation of hepatocellular carcinoma
TLDR
It was concluded that the CNP may represent a useful predictor for recurrence and prognosis in patients with HCC treated with RFA.
The prognostic and predictive value of the combination of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in patients with hepatocellular carcinoma who receive transarterial chemoembolization therapy
TLDR
The NLR–PLR score might be a useful predictor for patients with HCC who receive transarterial chemoembolization (TACE) therapy, and showed that the AUROC values of the NLR-PLR scores were consistently higher than those of NLR and PLR.
Preoperative Neutrophil-to-Lymphocyte Ratio Plus Platelet-to-Lymphocyte Ratio Predicts the Outcomes after Curative Resection for Hepatocellular Carcinoma
TLDR
The preoperative NLR-PLR is predictive of both OS and RFS in patients with HCC undergoing curative liver resection, validate combined preoperative Neutrophil-to-Lymphocyte ratio (NLR) and PLR in predicting overall survival and recurrence free survival in patients who underwent curative resection for HCC.
Prognostic and clinicopathological significance of Gamma-Glutamyltransferase in patients with hepatocellular carcinoma
TLDR
This meta-analysis shows that high pretreatment serum GGT level is significantly correlated with poor survival and unfavorable clinicopathological features in HCC patients, suggesting that pretreatment Serum GGT may be an economical and effective prognostic biomarker for H CC patients.
Preoperative serum pre-albumin as an independent prognostic indicator in patients with localized upper tract urothelial carcinoma after radical nephroureterectomy
TLDR
Low preoperative pre-albumin level but not preoperative hypoalbuminemia is a negative independent prognostic factor for survival outcome in patients with UTUC undergoing radical nephroureterectomy.
Preoperative fibrinogen to prealbumin ratio as a novel predictor for clinical outcome of hepatocellular carcinoma.
TLDR
Preoperative FPR was superior to other biomarkers to independently predict survival of HCC patients, and it could identify the patients who could benefit from adjuvant chemotherapy.
Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging.
TLDR
Adding AFP and ascites to the BCLC staging classification can improve prognosis prediction for early and intermediate stages of hepatocellular carcinoma.
...
...