Combination of stromal-derived factor-1alpha and vascular endothelial growth factor gene-modified endothelial progenitor cells is more effective for ischemic neovascularization.

@article{Yu2009CombinationOS,
  title={Combination of stromal-derived factor-1alpha and vascular endothelial growth factor gene-modified endothelial progenitor cells is more effective for ischemic neovascularization.},
  author={Jian-Xing Yu and Xue-fei Huang and Wei-ming Lv and Cai-sheng Ye and X Peng and Hui Zhang and Long-bin Xiao and Shenming Wang},
  journal={Journal of vascular surgery},
  year={2009},
  volume={50 3},
  pages={608-16}
}
BACKGROUND Recruitment and entrapment of bone marrow-derived endothelial progenitor cells (EPCs) is important in vascular endothelial growth factor (VEGF)-induced angiogenesis. EPC mobilization and differentiation are modulated by stromal-derived factor-1alpha (SDF-1alpha/CXCL12), another important chemokine. In this study, we investigated the hypothesis that SDF-1alpha and VEGF might act synergistically on EPC-mediated vasculogenesis. METHODS EPCs were isolated and cultured from human… CONTINUE READING
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