Combination of procainamide and quinidine for better tolerance and additive effects for ventricular arrhythmias.

@article{Kim1985CombinationOP,
  title={Combination of procainamide and quinidine for better tolerance and additive effects for ventricular arrhythmias.},
  author={S. G. Kim and Steve. Seiden and Jeffrey A. Matos and LAWRENCE E. Waspe and John D Fisher},
  journal={The American journal of cardiology},
  year={1985},
  volume={56 1},
  pages={
          84-8
        }
}
Comparison of individual and combined effects of procainamide and amiodarone in patients with sustained ventricular tachyarrhythmias.
TLDR
Sustained ventricular tachycardia was inducible in all 35 patients during treatment with procainamide alone and with amiodarone alone, and during combination therapy, VT initiation was prevented in only two (6%) patients.
Efficacy of disopyramide and mexiletine used alone or in combination in the treatment of ventricular premature beats
TLDR
When the single use of neither disopyramide nor mexiletine single-drug therapy is effective, it is worth-while to try combination therapy.
Rapid suppression of spontaneous ventricular arrhythmias during oral amiodarone loading.
TLDR
Oral amiodarone given in loading doses produces rapid and dramatic reductions in spontaneous ventricular arrhythmias within 72 hours, and prolongation of the QT interval exhibited a similar time course.
Combination Antiarrhythmic Drug Therapy For Ventricular Tachyarrhythmias
TLDR
It seems warranted to perform further studies to explore the combination of two antiarrhythmic agents with complimentary electrophysiologic activities and differing toxicities in larger populations and to test new combinations developed on the basis of pharmacodynamic principles.
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References

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Mexiletine in the Treatment of Resistant Ventricular Arrhythmias: Enhancement of Efficacy and Reduction of Dose‐related Side Effects by Combination with Quinidine
TLDR
It is concluded that combinations of drugs with different electrophysiologic properties may provide enhanced antiarrhythmic efficacy and mexiletine limited the quinidine-induced increase in QTc interval.
Antiarrhythmic Drug Effect Mimicked by Spontaneous Variability of Ventricular Ectopy
TLDR
Spontaneous variability in ventricular ectopic beats causes serious problems when using ECG monitoring to evaluate antiarrhythmic drug response in individual patients, so examining group response rather than individual patient response minimizes the effect of spontaneous variability.
Management of patients with malignant ventricular arrhythmias.
Limitations of Routine Long-Term Electrocardiographic Monitoring to Assess Ventricular Ectopic Frequency
TLDR
It is determined that to distinguish a reduction in VPD frequency attributable to therapeutic intervention rather than biologic or spontaneous variation alone required a greater than 83% reduction inVPD frequency if only two 24-hour monitoring periods were compared, and greater than 65% reduction if two 72-hour periods wereCompared.
Spontaneous Variability of Complex Ventricular Arrhythmias Detected by Long‐term Electrocardiographic Recording
Variations in the frequency of complex ventricular arrhythmias were evaluated by consecutive 24-hour long-term electrocardiographic recordings over 4 days using a two-channel recorder and
Intermittent intravenous procaine amide to treat ventricular arrhythmias. Correlation of plasma concentration with effect on arrhythmia, electrocardiogram, and blood pressure.
Abstract Twenty patients with ventricular arrhythmias were treated with procaine amide to determine an antiarrhythmic plasma drug concentration range and to observe procaine amide's effect on blood...
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