Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma.

@article{Jokoji2010CombinationOM,
  title={Combination of morphological feature analysis and immunohistochemistry is useful for screening of EML4-ALK-positive lung adenocarcinoma.},
  author={Ryu Jokoji and Takashi Yamasaki and Seigo Minami and Kiyoshi Komuta and Yasushi Sakamaki and Kengo Takeuchi and Masahiko Tsujimoto},
  journal={Journal of clinical pathology},
  year={2010},
  volume={63 12},
  pages={
          1066-70
        }
}
BACKGROUND A subset of lung cancers harbours the fusion gene echinoderm microtubule-associated protein-like-4-anaplastic lymphoma kinase (EML4-ALK). Recently, immunohistochemistry for ALK has shown sensitivity for the detection of EML4-ALK-positive lung adenocarcinoma almost equal to that of the fluorescence in situ hybridisation (FISH) assay. AIMS To study the clinicopathological features of EML4-ALK-positive lung adenocarcinoma in a large number of surgically resected samples using… CONTINUE READING

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