Combination of miRNA499 and miRNA133 Exerts a Synergic Effect on Cardiac Differentiation

@inproceedings{Pisano2015CombinationOM,
  title={Combination of miRNA499 and miRNA133 Exerts a Synergic Effect on Cardiac Differentiation},
  author={Federica Pisano and Claudia Altomare and Elisabetta Cervio and Lucio Barile and Marcella Rocchetti and Maria Chiara Ciuffreda and Giuseppe Malpasso and Francesco Copes and Manuela Mura and Patrizia Danieli and Gianluca Viarengo and Antonio Zaza and Massimiliano Gnecchi},
  booktitle={Stem cells},
  year={2015}
}
Several studies have demonstrated that miRNA are involved in cardiac development, stem cell maintenance, and differentiation. In particular, it has been shown that miRNA133, miRNA1, and miRNA499 are involved in progenitor cell differentiation into cardiomyocytes. However, it is unknown whether different miRNA may act synergistically to improve cardiac differentiation. We used mouse P19 cells as a cardiogenic differentiation model. miRNA499, miRNA1, or miRNA133 were transiently over-expressed in… CONTINUE READING