Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis

@article{Li2008CombinationOM,
  title={Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis},
  author={Zengshan Li and Latonya M Carrier and Aditi Belame and A. Thiyagarajah and V. Salvo and M. Burow and B. Rowan},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={118},
  pages={33-43}
}
To investigate the therapeutic effect of methylselenocysteine (MSC) combined with tamoxifen in MCF-7 breast cancer xenograft and the underlying mechanisms. MCF-7 breast cancer xenograft was established in ovariectomized female athymic nude mice and treated with tamoxifen and/or MSC. Tumor size was measured twice a week. Immunohistochemistry and TUNEL assays were used to measure ERα expression, ERα target genes (progesterone receptor (PR) and cyclin D1 expression), Ki-67 index, apoptosis and… Expand
Tamoxifen lowers the MMP-9/TIMP-1 ratio and inhibits the invasion capacity of ER-positive non-small cell lung cancer cells.
Distribution and inhibition effect of Seleno-L-Methionine on 4T1 mouse mammary carcinoma.
Selenium Induces an Anti-tumor Effect Via Inhibiting Intratumoral Angiogenesis in a Mouse Model of Transplanted Canine Mammary Tumor Cells
Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence
Dietary selenium supplementation modifies breast tumor growth and metastasis
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Attenuation of estrogen receptor alpha (ERalpha) signaling by selenium in breast cancer cells via downregulation of ERalpha gene expression.
Antiestrogenic Glyceollins Suppress Human Breast and Ovarian Carcinoma Tumorigenesis
Se-(methyl)selenocysteine (MSC) potentiates the antitumor activity of irinotecan against human tumor xenografts and protects against drug induced toxicity.
...
1
2
3
4
...