Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer.

@article{Donnem2010CombinationOL,
  title={Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer.},
  author={Tom Donnem and Khalid I. Al-Shibli and Sigve Andersen and Samer Al-Saad and L T Busund and Roy Martin Bremnes},
  journal={Cancer},
  year={2010},
  volume={116 18},
  pages={4318-25}
}
BACKGROUND There seems to be a close interplay between angiogenesis and the immune system. The authors of this report investigated the prognostic role of angiogenic markers in coexpression with immune system markers in patients with nonsmall cell lung cancer (NSCLC). METHODS Tumor resection samples from 335 patients with stage I to IIIA NSCLC were obtained, and tissue microarrays were constructed. Immunohistochemistry was used to evaluate the expression of vascular endothelial growth factor… CONTINUE READING

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