Combination of integrin-binding peptide and growth factor promotes cell adhesion on electron-beam-fabricated patterns.

@article{Kolodziej2012CombinationOI,
  title={Combination of integrin-binding peptide and growth factor promotes cell adhesion on electron-beam-fabricated patterns.},
  author={Christopher M Kolodziej and Sung Hye Kim and Rebecca M Broyer and Sina S Saxer and Caitlin G. Decker and Heather D Maynard},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 1},
  pages={247-55}
}
Understanding and controlling cell adhesion on engineered scaffolds is important in biomaterials and tissue engineering. In this report we used an electron-beam (e-beam) lithography technique to fabricate patterns of a cell adhesive integrin ligand combined with a growth factor. Specifically, micron-sized poly(ethylene glycol) (PEG) hydrogels with aminooxy- and styrene sulfonate-functional groups were fabricated. Cell adhesion moieties were introduced using a ketone-functionalized arginine… CONTINUE READING