Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery.

@article{Liu2014CombinationOF,
  title={Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery.},
  author={Shuyuan Liu and Yinglong Hou and Xu Chen and Yuan Gao and Hui Li and Shujuan Sun},
  journal={International journal of antimicrobial agents},
  year={2014},
  volume={43 5},
  pages={395-402}
}
The past decades have witnessed a dramatic increase in invasive fungal infections, especially candidiasis. Despite the development of more effective new antifungal agents, fluconazole (FLC) is still widely used in the clinic because of its efficacy and low toxicity. However, as the number of patients treated with FLC has increased, FLC-resistant Candida albicans isolates emerge more frequently. In addition, biofilm-associated infections are commonly encountered and their resistance poses a… CONTINUE READING
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