Combination of cisplatin/S-1 in the treatment of patients with advanced gastric or gastroesophageal adenocarcinoma: Results of noninferiority and safety analyses compared with cisplatin/5-fluorouracil in the First-Line Advanced Gastric Cancer Study.

@article{Ajani2013CombinationOC,
  title={Combination of cisplatin/S-1 in the treatment of patients with advanced gastric or gastroesophageal adenocarcinoma: Results of noninferiority and safety analyses compared with cisplatin/5-fluorouracil in the First-Line Advanced Gastric Cancer Study.},
  author={Jaffer A. Ajani and Marc Buyse and Mikhail Lichinitser and Vera Gorbunova and Gyorgy Bodoky and Jean Yves Douillard and Stefano Cascinu and Volker Heinemann and Renata E Zaucha and Alfredo Carrato and David Ferry and Vladimir M. Moiseyenko},
  journal={European journal of cancer},
  year={2013},
  volume={49 17},
  pages={
          3616-24
        }
}
BACKGROUND The aim of developing oral fluorouracil (5-FU) is to provide a more convenient administration route with similar efficacy and the best achievable tolerance. S-1, a novel oral fluoropyrimidine, was specifically designed to overcome the limitations of intravenous fluoropyrimidine therapies. PATIENTS AND METHODS A multicentre, randomised phase 3 trial was undertaken to compare S-1/cisplatin (CS) with infusional 5-FU/cisplatin (CF) in 1053 patients with untreated, advanced gastric… CONTINUE READING
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Phase III study comparing oxaliplatin plus S-1 with cisplatin plus S-1 in chemotherapy-naïve patients with advanced gastric cancer.

Annals of oncology : official journal of the European Society for Medical Oncology • 2015
View 11 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Design and analysis of non-inferiority mortality trials in oncology.

Statistics in medicine • 2003
View 3 Excerpts
Highly Influenced

a report of the V325 Study Group

E VanCutsem, VM Moiseyenko, +3 authors fluorouracil as first-line therapy for advanced gastric cancer
J Clin Oncol 2006;24:4991–7. 3624 J.A. Ajani et al. / European Journal of Cancer 49 • 2013

Meta-analyses of 22 randomized trials assessing the influence of chemotherapy in advanced/recurrent gastric cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2011
View 1 Excerpt

The role of chemotherapy in metastatic gastric cancer

F Pasini, AP Fraccon, G. De Manzoni
Anticancer Res • 2011
View 1 Excerpt

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