Combination of carvacrol with methotrexate suppresses Complete Freund's Adjuvant induced synovial inflammation with reduced hepatotoxicity in rats.

@article{Banji2014CombinationOC,
  title={Combination of carvacrol with methotrexate suppresses Complete Freund's Adjuvant induced synovial inflammation with reduced hepatotoxicity in rats.},
  author={Otilia J. F. Banji and David Banji and N. Soumya and Kiran Kumar Chilipi and Chandramore Kalpana and C H Kranthi Kumar and Anbarasu Annamalai},
  journal={European journal of pharmacology},
  year={2014},
  volume={723},
  pages={
          91-8
        }
}
The present study evaluated the therapeutic benefit of the combination of carvacrol, an isoprenoid having potential anti-inflammatory action, with methotrexate in suppressing Complete Freund's Adjuvant induced arthritis and attenuating methotrexate induced hepatic damage. Arthritis was induced in rats with Complete Freund's Adjuvant. Animals received methotrexate (2mg/kg) intraperitonealy once a week for 5 weeks alone and along with carvacrol orally (50 and 100mg/kg) respectively from the 10th… CONTINUE READING
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