Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells.

@article{Xiao2008CombinationOA,
  title={Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells.},
  author={H. G. Xiao and Qiang Zhang and Yong Lin and B. Somasekhara Reddy and Chung S Yang},
  journal={International journal of cancer},
  year={2008},
  volume={122 9},
  pages={2115-24}
}
Previous studies in animal models have shown enhanced efficacy of a combined treatment of statins and Nonsteroidal anti-inflammatory drugs against colorectal cancer development. In our study, we investigated the combinational effects of atorvastatin and celecoxib in 2 human colon cancer cell lines HCT116 and HT29. Celecoxib moderately inhibited the growth of both cell lines with a similar IC(50) of 40-50 microM, whereas atorvastatin showed stronger growth inhibitory effect in HCT116 cells than… CONTINUE READING

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