Combination of artemisinin-based natural compounds from Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies.

@article{Li2018CombinationOA,
  title={Combination of artemisinin-based natural compounds from Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies.},
  author={Jing Li and Chao Zhang and Muxin Gong and Manyuan Wang},
  journal={Phytotherapy research : PTR},
  year={2018},
  volume={32 7},
  pages={
          1415-1420
        }
}
Currently, the most effective antimalarial is artemisinin, which is extracted from the leaves of medicinal herb Artemisia annua L. (A. annua). Previous studies showed that the complex chemical matrix of A. annua could enhance both the bioavailability and efficacy of artemisinin. The present study aims to evaluate the efficacy and pharmacokinetic properties of a combination therapy based on artemisinin and 3 components from A. annua with high content (arteannuin B, arteannuic acid, and… CONTINUE READING

Figures, Tables, and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 16 REFERENCES

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

  • Clinical pharmacology and therapeutics
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

In vivo antimalarial activity of alpha‐ mangostin and the new xanthone delta‐mangostin

Y. Upegui, S. M. Robledo, +4 authors F. ... Echeverri
  • Phytotherapy Research,
  • 2015
VIEW 1 EXCERPT