Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions.

@article{Gasparini2005CombinationOA,
  title={Combination of antiangiogenic therapy with other anticancer therapies: results, challenges, and open questions.},
  author={Giampietro Gasparini and Raffaele Longo and Massimo Fanelli and Beverly A Teicher},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2005},
  volume={23 6},
  pages={1295-311}
}
Angiogenesis is necessary for tumor growth. Drug discovery efforts have identified several potential therapeutic targets on endothelial cells and selective inhibitors capable of slowing tumor growth or producing tumor regression by blocking angiogenesis in in vivo tumor models. Certain antiangiogenic therapeutics increase the activity of cytotoxic anticancer treatments in preclinical models. More than 75 antiangiogenic compounds have entered clinical trials. Most of the early clinical testing… CONTINUE READING
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