Combination of angiopoietin-1 and vascular endothelial growth factor gene therapy enhances arteriogenesis in the ischemic myocardium.

@article{Siddiqui2003CombinationOA,
  title={Combination of angiopoietin-1 and vascular endothelial growth factor gene therapy enhances arteriogenesis in the ischemic myocardium.},
  author={Anwar J. Siddiqui and Pontus Blomberg and Eva W{\"a}rdell and Irina Hellgren and Malihe Eskandarpour and Khalid Bin Islam and Christer Sylven},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={310 3},
  pages={
          1002-9
        }
}
We hypothesised that angiopoietin-1 (Ang-1), in conjunction with vascular endothelial growth factor (VEGF) gene therapy, can enhance arteriogenesis and angiogenesis during myocardial ischemia. Mice were given a single intramyocardial injection of saline, phVEGF-A(165) and phAng-1 or a combination thereof into the non-ischemic normal heart or into the ischemic border zone of the infarcted heart. In the normal and the ischemic myocardium, gene transfer of phVEGF-A(165) alone increased the… CONTINUE READING

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