Combination of anginex gene therapy and radiation decelerates the growth and pulmonary metastasis of human osteosarcoma xenografts

@article{Zhao2018CombinationOA,
  title={Combination of anginex gene therapy and radiation decelerates the growth and pulmonary metastasis of human osteosarcoma xenografts},
  author={Kai Zhao and Shang-You Yang and Jun Geng and X. Gong and W. Gong and Lin Shen and B. Ning},
  journal={Cancer Medicine},
  year={2018},
  volume={7},
  pages={2518 - 2529}
}
Investigate whether rAAV‐anginex gene therapy combined with radiotherapy could decrease growth and pulmonary metastasis of osteosarcoma in mice and examine the mechanisms involved in this therapeutic strategy. During in vitro experiment, multiple treatment regimes (rAAV‐eGFP, radiotherapy, rAAV‐anginex, combination therapy) were applied to determine effects on proliferation of endothelial cells (ECs) and G‐292 osteosarcoma cells. During in vivo analysis, the same multiple treatment regimes were… Expand
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