Combination of alpha-interferon with lamivudine reduces viral breakthrough during long-term therapy.


BACKGROUND AND AIM Viral breakthrough is frequently encountered during long-term lamivudine therapy, mostly associated with YMDD mutants. In this study, we investigated the effects of alpha-interferon (IFN-alpha) combined with lamivudine on the occurrence of viral breakthrough during long-term lamivudine therapy. METHODS Eighty-three patients with biopsy… (More)