Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of rat colonic crypts.

@article{Levi2009CombinationOA,
  title={Combination of aging and dimethylhydrazine treatment causes an increase in cancer-stem cell population of rat colonic crypts.},
  author={Edi Levi and Sandhya Misra and Jianhua Du and Bhaumik B. Patel and Adhip P. N. Majumdar},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={385 3},
  pages={430-3}
}
Aging is associated with increased incidence of colon cancers. It is also becoming evident that cancer stem cells (CSC) play a vital role in the pathogenesis and prognosis of colon cancer. Recently, we reported the presence of colon cancer stem-like cells in macroscopically normal mucosa in patients with adenomatous polyps and that they increase with aging, suggesting that aging may predispose the colon to carcinogenesis. In the current study we have examined the combined effects of aging and… CONTINUE READING
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