Combination of aerobic exercise and an arginine, alanine, and phenylalanine mixture increases fat mobilization and ketone body synthesis

  title={Combination of aerobic exercise and an arginine, alanine, and phenylalanine mixture increases fat mobilization and ketone body synthesis},
  author={Keisuke Ueda and C. Sanbongi and Shoko Takai and S. Ikegami and S. Fujita},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={1417 - 1424}
During exercise, blood levels of several hormones increase acutely. We hypothesized that consumption of a specific combination of amino acids (arginine, alanine, and phenylalanine; A-mix) may be involved in secretion of glucagon, and when combined with exercise may promote fat catabolism. Ten healthy male volunteers were randomized in a crossover study to ingest either A-mix (3 g/dose) or placebo (3 g of dextrin/dose). Thirty minutes after ingesting, each condition subsequently performed… Expand
An arginine, alanine, and phenylalanine mixture increases synthesis of ketone bodies during low-intensity exercise via stimulating glucagon secretion in men with obesity
Results indicate that pre-exercise ingestion of the A-mix supplement significantly accelerated hepatic ketone body synthesis via stimulation of glucagon secretion during exercise in men with obesity. Expand
The effects of phenylalanine on exercise-induced fat oxidation: a preliminary, double-blind, placebo-controlled, crossover trial
It is suggested that pre-exercise supplementation of phenylalanine may stimulate whole body fat oxidation and may promote fat oxidation when combined with exercise. Expand
Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults
A-mix supplementation in combination with physical activity promotion facilitated abdominal fat reduction in overweight adults. Expand
Dose-ranging pilot randomized trial of amino acid mixture combined with physical activity promotion for reducing abdominal fat in overweight adults
Compared with placebo, a medium or low dose of the amino acid mixture may facilitate abdominal fat reduction among overweight adults. Expand
Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated [Corrigendum]
This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for real-time analysis of the response of the immune system to Epstein-Barr virus. Expand


Amino Acid Mixture Enriched With Arginine, Alanine, and Phenylalanine Stimulates Fat Metabolism During Exercise.
Results suggest that preexercise ingestion of D-mix may stimulate fat metabolism, and the administration of AA mixtures could prove to be a useful nutritional strategy to maximize fat metabolism. Expand
Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men.
It was concluded that ingestion of 1,500 mg arginine and 1, 500 mg lysine immediately before resistance exercise does not alter exercise-induced changes in [GH] in young men, however, when the same amino acid mixture is ingested under basal conditions, the acute secretion of GH is increased. Expand
Effect of orally administered phenylalanine with and without glucose on insulin, glucagon and glucose concentrations.
  • F. Nuttall, K. Schweim, M. Gannon
  • Medicine, Biology
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2006
Phenylalanine in an amount moderately greater than that in a large protein meal stimulates an increase in insulin and glucagon concentration and markedly attenuates the glucose-induced rise in plasma glucose when ingested with glucose. Expand
Triglyceride/fatty acid cycling is increased after exercise.
It is concluded that the energy cost of the increased TG/FA cycling rate may account for as much as half of the delayed component of EPOC. Expand
The metabolic response to ingested glycine.
The data are compatible with the hypothesis that oral glycine stimulates the secretion of a gut hormone that potentiates the effect of insulin on glucose removal from the circulation. Expand
Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes
It appears that the GH/igF-1/IGFBP-3 complex may be the major player in muscle tissue response to short-term resistance training after arg and orn supplementation. Expand
Independence of the effects of epinephrine, glucagon, and adrenocorticotropin on glucose utilization from those on lipolysis in isolated rat adipose cells.
It is suggested that the adenyl cyclase system for the synthesis of adenosine 3',5'-cyclic monophosphate in adipocytes contains at least two different types of activation receptor sites for hormones, and that PGE1 binds to only one type of site while the β-adrenergic blockers are effective against both types. Expand
Glucagon stimulation of brown adipose tissue growth and thermogenesis.
The ability of administered glucagon to produce alterations in brown adipose tissue similar to changes produced by accepted stimuli of brown fat activity: cold, norepinephrine, and overfeeding is investigated. Expand
Effect of alanine and glycine on glucagon secretion in postabsorptive and fasting obese man.
The glucose increase observed within 30 min of a supraphysiologic alanine infusion in subjects fasted for 2 or more weeks may be secondary to glucagonmediated glycogen breakdown, but despite equivalent glucagon rises in the other two study periods, no significant rise in blood sugar was noted. Expand
Role of changes in insulin and glucagon in glucose homeostasis in exercise.
During light exercise there must be a reduction in insulin concentration and/or an increase in glucagon concentration if plasma glucose homeostasis is to be maintained, and if such changes do not occur, hypoglycemia, and hence exhaustion, may occur. Expand