Combination of adenovirus and cross-linked low molecular weight PEI improves efficiency of gene transduction.

@article{Han2010CombinationOA,
  title={Combination of adenovirus and cross-linked low molecular weight PEI improves efficiency of gene transduction.},
  author={Jianfeng Han and Dong Zhao and Zhirong Zhong and Zhirong Zhang and Tao Gong and Xun Sun},
  journal={Nanotechnology},
  year={2010},
  volume={21 10},
  pages={
          105106
        }
}
Recombinant adenovirus (Ad)-mediated gene therapy is an exciting novel strategy in cancer treatment. However, poor infection efficiency with coxsackievirus and adenovirus receptor (CAR) down-regulated cancer cell lines is one of the major challenges for its practical and extensive application. As an alternative method of viral gene delivery, a non-viral carrier using cationic materials could compensate for the limitation of adenovirus. In our study, adenovectors were complexed with a new… CONTINUE READING

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