Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo

@article{Ulasov2009CombinationOA,
  title={Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo},
  author={Ilya V Ulasov and Adam M Sonabend and Satyabrata Nandi and Andrey Ilyich Khramtsov and Yanxiao Han and Maciej S. Lesniak},
  journal={British Journal of Cancer},
  year={2009},
  volume={100},
  pages={1154 - 1164}
}
Conditionally replicative adenoviruses (CRAds) represent a novel treatment strategy for malignant glioma. Recent studies suggest that the cytopathic effect elicited by these vectors is mediated through autophagy, a form of programmed cell death. Likewise, temozolomide (TMZ), a chemotherapeutic agent used for the treatment of malignant gliomas, also triggers autophagic cell death. In this study, we examined the potential to combine the two treatments in the setting of experimental glioma. In… CONTINUE READING
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