Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice.

@article{Kuzmin2006CombinationOA,
  title={Combination of adenosine A1 and A2A receptor blocking agents induces caffeine-like locomotor stimulation in mice.},
  author={Alexander Kuzmin and Bj{\"o}rn Johansson and Lydia Gimenez and Sven-Ove Ogren and Bertil B. Fredholm},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2006},
  volume={16 2},
  pages={129-36}
}
The spontaneous locomotor activity of C57BL/6J mice was examined, using an automated detection system based on infra-red beams, after administration of caffeine (3-30 mg/kg, i.p.), the adenosine A(2A) receptor selective antagonist SCH 58261 (0.312-2.5 mg/kg, i.p.) and the A(1) selective antagonist DPCPX (1.25-5 mg/kg, i.p.). SCH 58261 failed to influence motor activity in mice habituated to the test environment. DPCPX produced a small increase in motility and locomotion (significant at the dose… CONTINUE READING
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