Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells.

@article{Lin2004CombinationOA,
  title={Combination of a hepatitis C virus NS3-NS4A protease inhibitor and alpha interferon synergistically inhibits viral RNA replication and facilitates viral RNA clearance in replicon cells.},
  author={Kai Lin and Ann D. Kwong and Chao Shuang Lin},
  journal={Antimicrobial agents and chemotherapy},
  year={2004},
  volume={48 12},
  pages={4784-92}
}
The present standard of care for hepatitis C virus (HCV) infection is pegylated alpha interferon (IFN-alpha) in combination with ribavirin. However, specific antivirals such as HCV NS3-NS4A protease inhibitors are now in clinical development, and these agents can potentially be used in combination with the present treatments. Therefore, it is important to investigate the potential benefits or adverse effects of these new combinations by using available in vitro HCV culture systems first. In the… CONTINUE READING

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Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research • 2003

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