Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer

  title={Combination of a MDR1-targeted replicative adenovirus and chemotherapy for the therapy of pretreated ovarian cancer},
  author={Daniel T. Rein and Anne K Volkmer and Gerd Johannes Bauerschmitz and Ines Beyer and Wolfgang Janni and M Fleisch and Anne Kathrin Welter and Dirk Olaf Bauerschlag and Thomas Sch{\"o}ndorf and Martina Breidenbach},
  journal={Journal of Cancer Research and Clinical Oncology},
Targeted oncolytic adenoviruses capable of replication selectively in cancer cells are an appealing approach for the treatment of various cancer types refractory to conventional therapies. The aim of this study was to evaluate the effect of Ad5/3MDR1E1, a multidrug resistance gene 1 (MDR1)-targeted fiber-modified replication-competent adenovirus for the therapy of platinum-pretreated ovarian cancer in combination with cytostatic agents. MDR1-specific tumor cell killing of Ad5/3MDR1E1 was… CONTINUE READING


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